Kre-Alkalyn Energy is a combination of Kre-Alkalyn® and Chocamine®, designed to improve strength, athletic performance and muscle mass, as well as mood and memory. Kre-Alkalyn® is a very stable, bioavailable and pH buffered form of the well-researched creatine monohydrate. Most creatine formulas on the market have a pH below 7, while Kre-Alkalyn® has a pH of 14 which stabilizes it so it does not convert into creatinine. Chocamine® is a proprietary formulation based on a potent chocolate extract including natural sources of polyphenols, theobromine, caffeine, biogenic amines (including synephrine) and amino acids.

Creatine (methylguanidine-acetic acid) is formed in the liver, kidneys, and pancreas from arginine, glycine and methionine and is transported through the bloodstream to various tissues. Creatine's most important role in human physiology is to contribute to maintenance of ATP levels. When ATP dissociates into ADP and phosphate to produce energy for muscle contraction and other metabolic functions, phosphocreatine donates its phosphate group to ADP to regenerate ATP. Therefore, greater phosphocreatine levels translate into greater cellular energy production. Aging is associated with lower skeletal muscle creatine and phosphocreatine levels. After age 30, phosphocreatine resynthesis rates after exercise fall 8% per decade. Supplementation of creatine can raise skeletal muscle creatine levels 10-30% and phosphocreatine levels 10-40%. Creatine supplementation has been found to produce gains in strength, energy and muscle mass in people with various conditions and diseases. It also results in quicker restoration of energy after exertion and therefore improves performance in repetitive bouts of very high intensity exercise. Typical responses to creatine supplementation are an additional 10 to 15 % increase in strength and an additional 1 to 3 % increase in muscle mass over one to three months of resistance exercise training.

Creatine and Cardiovascular Health

Congestive heart failure patients supplemented with creatine have exhibited signs of enhanced skeletal muscle metabolism with reduced lactate and ammonia accumulation. Creatine improved both strength and endurance in this patient population. Creatine has a positive effect on lipids. Creatine supplementation has been found to lower elevated serum cholesterol and triglyceride levels. One study found a 6% reduction in total cholesterol and a 23% reduction in triglycerides and VLDL cholesterol after eight weeks of creatine supplementation. Combining creatine with exercise appears to be synergistic in lowering cholesterol. In one study, creatine even lowered homocysteine when taken (at a dose of two times the participants’ creatinine levels) along with a multivitamin, more effectively than multivitamin alone.

Creatine and Anti-Aging

Creatine affects many of the top ten markers of biological aging including loss of muscle mass, drop in resting metabolic rate, aerobic capacity, the body’s ability to regulate its internal temperature, glucose tolerance, and bone density. Creatine supplementation has been found to reduce n-telopeptide levels (a biochemical marker for bone loss), and when combined with resistance training, creatine increased bone mineral content. Creatine supplementation has been shown to improve intelligence and working memory, and to reduce the effects of sleep deprivation. Creatine supplementation has also shown a beneficial effect on mood, cognitive and psychomotor performance. In animal models of traumatic brain injury, creatine supplementation appeared to protect neurons by maintaining mitochondrial bioenergetics. In an animal model of Parkinson's disease, animals pre-supplemented with creatine experienced only a 10% decrease in brain dopamine levels compared to 70% reduction in non-supplemented animals. In animal models of Alzheimer’s disease, creatine protected hippocampal neurons from ß-amyloid toxicity, and therefore could potentially reduce the formation of plaques.

Kre-Alkalyn®:

Why is it important for creatine to be alkaline?
Finally there is a creatine on the market that does not cause nausea, diarrhea, and cramps or bloating because it does not convert to creatinine, a metabolite of creatine, in the bloodstream before it reaches muscle cells. The unique technology behind Kre-Alkalyn® gives it complete stability, as confirmed via infrared testing. It is the only creatine with a stable pH above 12, which reduces side-effects often a result of extramuscular conversion to creatinine. Most of the human research on standard creatine powder uses between 5-20 grams. Kre-Alkalyn® stabilized creatine is effective at much lower doses (between 1-5 grams) so no “loading” is necessary. Kre-Alkalyn® is an approved supplement by the International Olympic Committee.

Chocamine®

Chocamine® is a proprietary, patented cocoa (Theobroma cacao) extract that has the proven health benefits of chocolate without the sugar, fat and dairy of chocolate candy. The beneficial effects of chocolate come from a complex matrix of compounds. Chocamine® provides these in a unique and synergistic blend. Chocamine® is standardized for several important constituents, including proven, safe and natural non-ephedra thermogenic compounds, as well as mood, energy and athletic performance enhancing substances such as:

Methyl-Xanthine Alkaloids (theobromine and theophylline) – Many athletes rely on ergogenic aids for performance enhancement. Theobromine and caffeine, known stimulants and appetite suppressants found in chocolate, work synergistically as ergogenic aids.

Biogenic Amines (phenylethylamine-PEA, tyramine, octopamine, synephrine and others) – Perhaps chocolate is given on Valentines Day because it contains PEA, a mood modulating chemical similar to that which is released when a person is “in love”.

Polyphenols – Chocolate is a rich source of these flavonoids. Besides their antioxidant effect, in vitro and in vivo studies suggest that chocolate polyphenols may modulate nitric oxide to improve blood pressure, decrease LDL oxidation, regulate platelet activation and have a positive effect on eicosanoid balance.

Magnesium – Chocamine® contains this heart-protective mineral that is often deficient in diabetics and cardiovascular patients.

Who should take Kre-Alkalyn Energy?™

Those wishing to: attain greater and more focused athletic performance, maximize athletic workouts and accelerate the building of muscle mass, safely burn additional fat, and those wanting the additional health benefits of both creatine and chocolate. Considering Chocamine® contains magnesium, appetite reducers and mood enhancers, it may prove helpful for common symptoms of PMS. Creatine, as well as several of the aforementioned compounds found in Chocamine®, have been implicated with improving motor performance in sleep deprived individuals.

Who should not take Kre-Alkalyn Energy™?

Due to the fact that this formula contains both caffeine and tyramine it should be avoided by anyone with sensitivities to these ingredients. Individuals with a history of renal disease or taking nephrotoxic medications should not take Kre-Alkalyn Energy™.

Is long-term, high dose creatine supplementation safe?

This is the conclusion of a study published in the British Journal of Sports Medicine after
giving 48 subjects 20 g of creatine for 5 days followed by 3 g creatine for 9 weeks: “Interpretation: These data provide evidence that there are no obvious adverse effects of acute or more chronic creatine supplementation on the haematological indices measured, nor on hepatic, muscle, and renal function. Therefore there is no apparent health risk associated with creatine supplementation to healthy people when it is ingested in quantities that have been scientifically proven to increase muscle creatine stores.”

How to take Kre-Alkalyn Energy™:

2 capsules, twice daily, with grape juice or a meal that contains both protein and carbohydrates, especially post-workout.

Synergistic supplements to consider taking along with Kre-Alkalyn Energy™:

Lipoic Acid, Taurine, Electrolyte Essentials, Amino Essentials, Whey Superior Protein or Whey Superior MR, and Ribose.

Kre-Alkalyn Energy

Advanced Athletic Performance (120ct)

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creatine to the brain. J Cereb Blood Flow Metab 2002 Nov;22(11):1327-3
3. Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons. J Neurochem 1968-1978; 74(5).
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13.Robinson TM, Sewell DA, Casey A, Steenge G, Greenhaff PL. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle
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